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Saturday, September 24, 2011

A BREAK THROUGH IN CANCER TREATMENT: VIRUS THAT TREATS CANCER





WHAT IS CANCER?



We will discuss in brief about cancer. Cancer is a large, heterogeneous class of diseases in which a group of cells display uncontrolled growth, invasion that intrudes upon and destroys adjacent tissues, and often metastasizes, wherein the tumor cells spread to other locations in the body via the lymphatic system or through the bloodstream.



An Ottawa-based research team has developed a virus that is showing promise as a new way of attacking and shrinking cancer tumours while leaving healthy tissue alone.
It's early days in the still-experimental field of therapeutic cancer viruses, called oncolytic viruses. But this new study from researchers from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa advances the field a little further by showing that the virus is safe in most patients.
For the study, researchers recruited 23 advanced cancer patients whose cancer had spread to multiple organs. All had failed to respond to the usual treatments and all were in the final stages of the disease.

The patients agreed to receive a single infusion of an experimental virus into their blood, called JX-594.
JX-594 is a form of vaccinia virus that's been used as a live vaccine against smallpox. The JX-594 virus has been genetically engineered to enhance its natural anti-cancer properties. The virus is not smallpox and it's not strong enough to infect healthy cells, but tumour cells, which are inherently weak, are susceptible to it.
The doctors tried out five doses of the virus, and then took biopsies of the tumours eight to 10 days later.
The researchers found that seven of the eight patients in the highest dose groups had evidence that the virus was in place and replicating in their tumours and not in normal tissues.
What's more, six of eight patients in the two highest dose groups experienced a shrinking or stabilization of their tumours, while those in lower dose groups saw less of this effect.
None of the 23 patients experienced significant side effects from the virus injection, with the most common side effect being mild to moderate flu-like symptoms that lasted less than one day.
The study, which is published in the journal Nature, was designed primarily to test the safety of the virus, not to cure the patients. In fact, some of the patients later died of their disease.
But the observation that some patients saw their tumours shrink was a welcome discovery.
Dr. John Bell, one of the study's co-authors and a researcher at OHRI says it's exciting that the virus led to results after just one dose.
"Of course, we will need to do more trials to know if this virus can truly make a difference for patients," he said in a statement.
Bell says the advantage of therapeutic viruses is that they can be sent through the blood, infect the cancer tumours and leave the healthy tissue alone. It's possible that oncolytic viruses could one day offer an alternative to conventional chemotherapy and radiation treatment, which tend to destroy healthy cells as well as cancer cells.
"Oncolytic viruses are unique because they can attack tumours in multiple ways, they have very mild side effects compared to other treatments, and they can be easily customized for different kinds of cancer," Bell said.
"We're still in the early stages of testing these viruses in patients, but I believe that someday, viruses and other biological therapies could truly transform our approach for treating cancer."
JX-594 was developed with Jennerex Inc., a biotherapeutics company co-founded by Dr. Bell in Ottawa and Dr. David Kirn in San Francisco.
The study was funded in part by Jennerex, as well as the Terry Fox Foundation, the Canadian Institutes of Health Research and the Ontario Institute for Cancer Research, and others.
Bell and his research team plan to do further tests on many more patients to show the treatment actually works and that the body doesn't learn to resist the virus over time.
A Phase 2 trial is to start soon aimed at patients with end-stage liver cancer or colon cancer.

Wednesday, September 21, 2011

Marketing Research Proposal

Marketing Research Proposal Executive summary -- the proposal should begin with a summary of the major points from each of the other sections, presenting an overview of the entire proposal Background -- the background of the problem, including the environmental context, should be discussed Problem definition/objectives of the research -- normally a statement of the problem, including the specific components, should be presented. If this statement has not been developed (in the case of problem identification research), the objectives of the marketing research project should be clearly specified approach to the problem -- at a minimum, a review of the relevant academic and trade literature should be presented, along with some kind of analytical model. If research questions and hypotheses have been identified, then he should be included in the proposal Research design -- the research designed adopted, whether exploratory, descriptive, or casual, should be specified. fieldwork/data collection -- the proposal should discuss how the data will be collected and he will collect it. If the field work is to be subcontracted to another supplier, this should be stated. Control mechanisms to ensure the quality of data collected should be described Data analysis -- the kind of data analysis that will be conducted and how the results will be interpreted should be described Reporting -- the proposal should specify whether intermediate reports will be presented and at what stages, what will be the form of the final report, and whether a formal presentation of the results will be made Cost and time -- the cost of the project and a time schedule, broken down by phases, should be presented. A CPM or PERT chart might be included. In large projects, a payment schedule is also worked out in advance Appendices -- any statistical or other information that is of interest to only a feed people should be contained in appendices

Nissan Sunny unveiled in India at Rs 5.78 lakh

Nissan Motor India has unveiled a mid-size sedan Sunny, which is priced in the range of Rs 5.78 lakh - Rs 7.68 lakh.
After the Nissan Micra, this is the auto manufacturer's second locally-made mass-market product, which it aims to give higher volumes in the upcoming festive season.
Moreover, the prices are uniform across India, though the sedan will be available in the initial stage only as a petrol model. The bookings of Nissan Sunny will commence from today and the deliveries will start from October 3. The Nissan Sunny will be giving strong competition to other vehicles like Maruti Suzuki Swift Dzire, Toyota Etios and Volkswagen Vento.

SkodaAuto India----premium sedan Laura RS

Laura RS
Car-maker SkodaAuto India has launched a new edition of its premium sedan Laura RS in India, priced at Rs 15.49 lakh (ex-showroom, Delhi).

Renault to commence phase II of India market strategy, plans new products to launch next year

French commercial vehicle manufacturer Renault, is all to commence the second phase of the India market strategy after the successful first phase completion this month with the establishment of its Fluence sedan and Koleos SUV brands in the premium car segment.
As per the business strategy for the second phase, the company may roll out an all new small car in the first few months of 2012. The new launches will be based on the same V-platform that supports the Nissan Micra and Sunny.
The new product are designed under the consideration of Indian market and will compete with Maruti Suzuki's Swift and the Hyundai i20. Moreover, in mid-2012 the company will launch its fourth product the SUV Duster which will compete with Mahindra's Scorpio and the Tata Safari.
As per the dealer of the company, the fifth product of the company, a new sedan, is positioned between the Volkswagen Vento and the Swift Dzire, is scheduled to be launched in the late next year. All planned 12 products are expected to come in by 2014.
Mr Len Curran, Vice-President, Sales and Marketing, Renault India, said, “Our target is to reach one lakh units by 2013. The two new vehicles will have above 60 per cent localisation and India will be the first market for this small car.”

Mylan's Indian arm Matrix Labs gets tentative approval from USFDA for AIDS tablets

 Matrix Laboratories, the Indian arm of drugmaker Mylan Inc, has received the tentative approval from the US Food and Drug Administration (USFDA) to market its generic Lamivudine, Tenofovir Disoproxil Fumarate tablets, used for treatment of AIDS/HIV.
Under the granted approval, Matrix Laboratories is permitted to market Lamivudine, Tenofovir Disoproxil Fumarate tablets in the strengths of 300 mg co-packaged with Nevirapine tablets in the strength of 200 mg.
Mr Heather Bresch, Mylan President, said, “The approval of Lamivudine, Tenofovir Disoproxil Fumarate tablets co-packaged with Nevirapine tablets is an important product developed by Matrix for the treatment of HIV/AIDS.”
Mr Robert J Coury, Mylan Vice Chairman and CEO, said, “This product approval is yet another important step in providing access to a range of critical HIV medications to patients in developing countries. Mylan and Matrix continue to make a significant contribution to bringing down the cost of these vital treatments through the expansion of our high-quality anti-retroviral franchise.”
The company secured the tentative approval from the US Food and Drug Administration (USFDA) through the President's Emergency Plan for AIDS Relief (PEPFAR).

Bayer Healthcare to acquire Pathway Medical Technologies

Bayer Healthcare to acquire Pathway Medical Technologies

Lilly Invests $30 Million in Partnership to Address Non-Communicable Diseases

Lilly Invests $30 Million in Partnership to Address Non-Communicable Diseases

Tuesday, September 13, 2011

Management Lessons from ‘3 Idiots’ Movie

1. Never Try To Be Successful
Success is the bye-product. Excellence always creates success. So, never run after the success, let it happen automatically in the life.


2. Freedom To Life
Don’t die before actual death. Live every moment to the fullest as you are going to
die today night. Life is gifted to humankind to live, live & live @ happiness.
3. Passion Leads To Excellence
When your hobby becomes your profession and passion becomes your profession. You will be able to lead up to excellence in the life. Satisfaction, pleasure, joy and love will be the outcome of following passion. Following your passion for years, you will surely become something one day.


4. Learning Is Very Simple
Teachers do fail. Learners never fail. Learning is never complicated or difficult. Learning is always possible whatever rule you apply.

5. Pressure At Head
Current education system is developing pressures on students’ head. University intelligence is useful and making some impact in the life but it cannot be at the cost of the life.


6. Life Is Emotion Management Not Intelligence Optimization 
Memory and regular study have definite value and it always helps you in leading a life. You are able to survive even if you can make some mark in the path of the life. With artificial intelligence, you can survive and win but you cannot prove yourself genius. Therefore, in this process genius dies in you.

7. Necessity Is The Mother Of Invention

Necessity creates pressure and forces you to invent something or to make it happen or to use your potentiality. Aamir Khan in this film, 3 idiots, is able to prove in the film by using vacuum pump at the last moment.


8. Simplicity is Life
Life is need base never want base. Desires have no ends. Simplicity is way of life and Indian culture highly stresses on simple living and high thinking, and this is the way of life: ‘Legs down to earth and eyes looking beyond the sky’


9. Industrial Leadership
Dean of the institute in 3 idiots is showing very typical leadership. He has his own principles, values and ideology, and he leads the whole institute accordingly. This is an example of current institutional leadership. In the present scenario, most of the institutes are fixed in a block or Squarish thinking.


10. Love Is Time & Space Free
Love is not time bound and space bound. It is very well demonstrated in this movie same love was demonstrated by Krishna and Meera. Love is border free, time free and space free.

11. Importance Of One Word In Communication 

If communication dies, everything dies. Each word has impact and value in communication. One word if used wrongly or emphasized wrongly or paused at a wrong place in communication what effect it creates and how is it affected is demonstrated very well in this movie.
12. Mediocrity Is Penalized
Middle class family or average talent or average institute is going to suffer and has to pay maximum price in the life if they do not upgrade their living standards. To be born poor or as an average person is not a crime but to die as an average person with middle class talent is miserable and if you are unable to optimize your potentiality and die with unused potentiality then that is your shameful truth. One should not die as a mediocre. He/she has to bring out genius inside him/her and has to use his/her potentiality to the optimum level.





Top 5 hollywood movies to be watched


Baby Boom
Glengarry Glen Ross

Up in the Air


The Pursuit of Happiness

Jerry Maguire


Industry & Economy / Economy : India hosts world pharma congress for the first time

Delegates at the 71st International Congress of FIP and World Congress of Pharmacy and Pharmaceutical Sciences visit a model drug store set up at the event venue in Hyderabad on Sunday. — Photo: P.V. Sivakumar3,000 delegates from over 120 countries participating in the event
The five-day World Congress of Pharmacy and Pharmaceutical Sciences-2011 and the 71st International Congress of International Pharmaceutical Federation began in Hyderabad today.
The theme of the congress is Compromising Safety and Quality, A Risky Path.
This is the first time in the Congress' 100-year history that India is hosting it. It is being held at Hyderabad International Convention Centre. About 3,000 delegates from over 120 countries are participating.
The event will have deliberations on issues relating to drugs. There will be talks on key issues relating to quality of drugs and medicines and their repercussions on public health.
The congress will have multiple panel discussions centred around the role of pharmacists in tackling the menace of counterfeit drugs, benchmarks to be set during production of medicines and regulatory reinforcements for building-in safety and quality.
The event is being hosted by the Indian Pharmaceutical Association. The President, Ms Pratibha Patil, inaugurated the programme.
At the congress, the World Health Organisation through its representative would present the initiatives taken by the global body to prevent irrational use of medicines and improve accessibility of essential drugs to the poorest of poor across the globe.
SOURCE:BUSINESS LINE

Indian pharma industry to be in global Top 5 by 2020: Study - Hindustan Times

Indian pharma industry to be in global Top 5 by 2020: Study - Hindustan Times

Monday, September 12, 2011

My industry internship@Creamline dairy products limited


Katiki water falls-Vizag

Waterfalls:KATIKI
It is located in Vizag district of Andhra Pradesh, about 7kms from BORRA CAVES.
Im amazed to see the water falls and the beauty of the place.Falls are about 1300m high and
the water was chilling all the time.
The way was little risky to reach the top...it ws slippery and way of about 1mt width where only
person can fit.
I along with my graduation friends were holding hands in a line to climb up.
we enjoyed a lot, but it was too late and the local private cabs didn't come and it was
getting dark and then we realized that we are in FOREST and everybody in the group were scared
about the wild animals and the radicals/naxals.
Finally only one cab came after 1 hour of waiting.The cab owner said "the other cab got a repair".
and we were 17members in one cab adjusted and he dropped some of us at one place saying that
the other cab is its way.It was really getting dark and after few minutes when the cab left with 9 of our group
A man came and was asking us money to reach ARAKU and he said us that he was a painter by profession and coming from so and so place and one of the local auto-rikshaw driver took me to a place and he showed him the place and offered him DRINK,he didnt remember what happened after that and when he woke up early in the morning at 4 am and realized that he was totally looted and nothing is left with him even his sweater and chappal.He came walking from morning to reach the place where we were standing.He said that the people who took him there mixed something in the drink and he was fortunate that any wild animal did nt attak him in that deep forest.
Our group really got scared hearing to the story and we were praying to god that other cab to reach soon, the cab didn't reach.we have no option than to wait and there is no mobile network to call our friends who left in the first cab.We saw each others faces and came together to sit together at the place....doubts came into our minds regarding the first cab , whether he took our place to the right place or not and will the second cab return to us.For a moment we lost hopes and we decided to take a lift from the vehicles coming passing through,but if some of us get the lift ,remaining will be alone and what about the first cab.we were in real confusion and waited there for more than 2 hours and finally the same first cab came dropping our friends and said that it was late due the railway gate.
That is the one of the wonderful experience in the VIZAG tour with my graduation friends.

 
 
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